Info
| ID | 3872 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 3, "O": 1, "P": 2} |
| Abbreviation | Complex 4 |
| SMILES | NC(CC(=O)O)C(=O)[O-].c1ccc(-c2ccccn2)nc1.c1ccc(P(CCCCP(c2ccccc2)c2ccccc2)c2ccccc2)cc1 |
TUCAN
C42H42N3O4P2Ru/(1-43)(2-79)(3-79)(4-44)(5-51)(6-45)(7-46)(8-57)(9-55)(10-72)(11-48)(12-80)(13-69)(14-69)(15-47)(16-52)(17-70)(18-68)(19-73)(20-53)(21-58)(22-56)(23-59)(24-70)(25-80)(26-62)(27-54)(28-60)(29-63)(30-61)(31-65)(32-64)(33-71)(34-50)(35-49)(36-67)(37-66)(38-76)(39-71)(40-85)(41-85)(42-91)(43-45)(43-57)(44-46)(44-57)(45-81)(46-81)(47-51)(47-82)(48-50)(48-72)(49-50)(49-74)(51-58)(52-55)(52-82)(53-56)(53-83)(54-59)(54-83)(55-58)(56-62)(59-62)(60-61)(60-84)(61-65)(63-64)(63-84)(64-65)(66-67)(66-68)(67-75)(68-73)(69-70)(69-79)(70-80)(71-76)(71-77)(72-86)(73-87)(74-75)(74-86)(75-87)(76-78)(76-85)(77-88)(77-91)(78-89)(78-90)(79-92)(80-93)(81-92)(82-92)(83-93)(84-93)(86-94)(87-94)(91-94)(92-94)(93-94)
Measurements (2)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| S180 | 42 | — | 10.1371/journal.pone.0105865 | 2014 |
| L-929 | 1.1e+02 | — | 10.1371/journal.pone.0105865 | 2014 |
🧬 Cell Death Types (1)
Apoptosis
high
«Flow cytometric analysis revealed that the [Ru(gly)(bipy)(dppb)]PF6 complex (2) inhibited the growth of the tumor cells by inducing apoptosis, as evidenced by an increased number of Annexin V-positive...»