Info
| ID | 3871 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"O": 1, "P": 4} |
| Abbreviation | Ru(GA) |
| SMILES | O=C([O-])c1cc(O)c(O)c(O)c1.c1ccc(P(CCP(c2ccccc2)c2ccccc2)c2ccccc2)cc1.c1ccc(P(CCP(c2ccccc2)c2ccccc2)c2ccccc2)cc1 |
TUCAN
C59H53O5P4Ru/(1-54)(2-55)(3-56)(4-62)(5-61)(6-63)(7-64)(8-57)(9-103)(10-68)(11-103)(12-67)(13-78)(14-65)(15-101)(16-101)(17-58)(18-59)(19-69)(20-60)(21-70)(22-66)(23-72)(24-104)(25-104)(26-76)(27-71)(28-73)(29-87)(30-75)(31-80)(32-79)(33-102)(34-102)(35-82)(36-84)(37-74)(38-77)(39-85)(40-83)(41-88)(42-86)(43-93)(44-81)(45-94)(46-89)(47-92)(48-95)(49-91)(50-90)(51-115)(52-116)(53-117)(54-56)(54-105)(55-61)(55-105)(56-62)(57-63)(57-107)(58-65)(58-107)(59-66)(59-108)(60-80)(60-108)(61-62)(63-64)(64-65)(66-78)(67-68)(67-72)(68-106)(69-70)(69-72)(70-106)(71-74)(71-76)(73-96)(73-98)(74-75)(75-87)(76-109)(77-85)(77-86)(78-80)(79-82)(79-111)(81-82)(81-84)(83-84)(83-111)(85-88)(86-93)(87-109)(88-110)(89-91)(89-94)(90-96)(90-99)(91-92)(92-95)(93-110)(94-112)(95-112)(96-100)(97-98)(97-99)(97-117)(98-115)(99-116)(100-113)(100-114)(101-102)(101-118)(102-119)(103-104)(103-120)(104-121)(105-118)(106-120)(107-118)(108-119)(109-120)(110-121)(111-119)(112-121)(115-122)(116-122)(117-122)(120-122)(121-122)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MDA-MB-231 | 0.81 | — | 10.1021/acs.molpharmaceut.8b01... | 2019 |
| MDA-MB-468 | 1 | — | 10.1021/acs.molpharmaceut.8b01... | 2019 |
| MCF-10A | 5.8 | — | 10.1021/acs.molpharmaceut.8b01... | 2019 |
🧬 Cell Death Types (1)
Apoptosis
high
«Ru(GA) complex presented selective cytotoxicity against TNBC over nontumor cells, inhibited its migration and invasion, and induced apoptosis.»