Info
| ID | 3869 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 2, "S": 2, "O": 2} |
| Abbreviation | Ru3 |
| SMILES | COc1ccc2cc(-c3nc4ccccc4[nH]3)c(=O)oc2c1.CS(C)=O.CS(C)=O.[Cl-].[Cl-] |
TUCAN
C21H24N2O5RuS2/(1-42)(2-42)(3-30)(4-27)(5-25)(6-28)(7-31)(8-26)(9-38)(10-32)(11-42)(12-43)(13-43)(14-29)(15-38)(16-43)(17-44)(18-44)(19-38)(20-44)(21-45)(22-45)(23-45)(24-46)(25-33)(25-34)(26-27)(26-39)(27-33)(28-39)(28-40)(29-30)(29-36)(30-31)(31-32)(32-35)(33-40)(34-37)(34-41)(35-36)(35-47)(36-46)(37-46)(37-47)(38-51)(39-51)(40-52)(41-48)(41-52)(42-53)(43-53)(44-54)(45-54)(47-55)(49-53)(50-54)(51-55)(52-55)(53-55)(54-55)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| NCI-H460 | 10 | — | 10.1021/acsmedchemlett.9b00098 | 2019 |
| T24 | 30 | — | 10.1021/acsmedchemlett.9b00098 | 2019 |
| A549 | 34 | — | 10.1021/acsmedchemlett.9b00098 | 2019 |
| SK-OV-3 | 46 | — | 10.1021/acsmedchemlett.9b00098 | 2019 |
| MGC-803 | 88 | — | 10.1021/acsmedchemlett.9b00098 | 2019 |
| HL-7702 | — | — | 10.1021/acsmedchemlett.9b00098 | 2019 |
🧬 Cell Death Types (1)
Apoptosis
high
«Ru2 induced NCI-H460 apoptosis via telomerase inhibition, which involved DNA damage, cell-cycle distribution, and S phase-protein down-regulation. Ru2 (0.30 μM, ca. 88.4%) induced the apoptosis ... in...»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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