Info
| ID | 3868 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"S": 2, "O": 2, "N": 2} |
| Abbreviation | Ru2 |
| SMILES | CS(C)=O.CS(C)=O.O=c1oc2cc(F)ccc2cc1-c1nc2ccccc2[nH]1.[Cl-].[Cl-] |
TUCAN
C20H21FN2O4RuS2/(1-24)(2-38)(3-38)(4-38)(5-39)(6-39)(7-39)(8-22)(9-29)(10-40)(11-40)(12-25)(13-26)(14-23)(15-27)(16-28)(17-40)(18-41)(19-41)(20-41)(21-42)(22-23)(22-32)(23-26)(24-26)(24-33)(25-27)(25-30)(27-37)(28-35)(28-37)(29-30)(29-31)(30-35)(31-34)(31-36)(32-33)(32-42)(33-43)(34-42)(34-43)(35-47)(36-44)(36-47)(37-48)(38-49)(39-49)(40-50)(41-50)(43-51)(45-49)(46-50)(47-51)(49-51)(50-51)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| NCI-H460 | 0.3 | — | 10.1021/acsmedchemlett.9b00098 | 2019 |
| A549 | 20 | — | 10.1021/acsmedchemlett.9b00098 | 2019 |
| T24 | 26 | — | 10.1021/acsmedchemlett.9b00098 | 2019 |
| SK-OV-3 | 36 | — | 10.1021/acsmedchemlett.9b00098 | 2019 |
| MGC-803 | 69 | — | 10.1021/acsmedchemlett.9b00098 | 2019 |
| HL-7702 | — | — | 10.1021/acsmedchemlett.9b00098 | 2019 |
🧬 Cell Death Types (1)
Apoptosis
high
«Ru2 induced NCI-H460 apoptosis via telomerase inhibition, which involved DNA damage, cell-cycle distribution, and S phase-protein down-regulation. Ru2 (0.30 μM, ca. 88.4%) induced the apoptosis ... in...»