Info
| ID | 3867 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"S": 2, "O": 2, "N": 2} |
| Abbreviation | Ru1 |
| SMILES | CS(C)=O.CS(C)=O.O=c1oc2ccccc2cc1-c1nc2ccccc2[nH]1.[Cl-].[Cl-] |
TUCAN
C20H22N2O4RuS2/(1-25)(2-31)(3-28)(4-39)(5-39)(6-39)(7-40)(8-40)(9-23)(10-29)(11-40)(12-41)(13-30)(14-24)(15-27)(16-26)(17-41)(18-41)(19-42)(20-42)(21-42)(22-43)(23-24)(23-34)(24-28)(25-26)(25-31)(26-27)(27-33)(28-29)(29-35)(30-32)(30-33)(31-37)(32-36)(32-38)(33-37)(34-35)(34-43)(35-44)(36-43)(36-44)(37-48)(38-45)(38-48)(39-49)(40-49)(41-50)(42-50)(44-51)(46-49)(47-50)(48-51)(49-51)(50-51)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| NCI-H460 | 16 | — | 10.1021/acsmedchemlett.9b00098 | 2019 |
| A549 | 41 | — | 10.1021/acsmedchemlett.9b00098 | 2019 |
| T24 | 53 | — | 10.1021/acsmedchemlett.9b00098 | 2019 |
| SK-OV-3 | 65 | — | 10.1021/acsmedchemlett.9b00098 | 2019 |
| MGC-803 | 91 | — | 10.1021/acsmedchemlett.9b00098 | 2019 |
| HL-7702 | — | — | 10.1021/acsmedchemlett.9b00098 | 2019 |
🧬 Cell Death Types (1)
Apoptosis
high
«Ru2 induced NCI-H460 apoptosis via telomerase inhibition, which involved DNA damage, cell-cycle distribution, and S phase-protein down-regulation. Ru2 (0.30 μM, ca. 88.4%) induced the apoptosis ... in...»