Info
| ID | 3866 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 6} |
| Abbreviation | 2 |
| SMILES | Oc1ccc(-c2nc3c4cccnc4c4ncccc4c3[nH]2)cc1.c1ccc2nc3c4cccnc4c4ncccc4c3nc2c1.c1ccc2nc3c4cccnc4c4ncccc4c3nc2c1 |
TUCAN
C55H32N12ORu/(1-36)(2-38)(3-34)(4-33)(5-65)(6-44)(7-35)(8-37)(9-41)(10-64)(11-43)(12-66)(13-39)(14-49)(15-48)(16-46)(17-52)(18-68)(19-45)(20-42)(21-55)(22-56)(23-50)(24-69)(25-54)(26-51)(27-47)(28-67)(29-53)(30-40)(31-93)(32-100)(33-38)(33-58)(34-44)(34-57)(35-36)(35-45)(36-77)(37-45)(37-79)(38-67)(39-43)(39-87)(40-42)(40-60)(41-56)(41-66)(42-64)(43-63)(44-68)(46-53)(46-83)(47-52)(47-62)(48-54)(48-82)(49-51)(49-69)(50-55)(50-63)(51-59)(52-65)(53-54)(55-87)(56-61)(57-70)(57-75)(58-71)(58-80)(59-73)(59-76)(60-78)(60-85)(61-74)(61-84)(62-72)(62-81)(63-86)(64-99)(65-94)(66-92)(67-96)(68-89)(69-90)(70-71)(70-88)(71-97)(72-73)(72-98)(73-91)(74-78)(74-92)(75-80)(75-89)(76-81)(76-90)(77-79)(77-88)(78-99)(79-97)(80-96)(81-94)(82-83)(82-98)(83-91)(84-85)(84-93)(85-95)(86-93)(86-95)(87-100)(94-101)(95-101)(96-101)(97-101)(98-101)(99-101)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MCF-7 | 12 | — | 10.1038/srep31973 | 2016 |
| HeLa | 14 | — | 10.1038/srep31973 | 2016 |
| HFF | — | — | 10.1038/srep31973 | 2016 |
🧬 Cell Death Types (1)
Autophagy
high
«quantifying LC3 levels revealed a distinct increase in the ratio of LC3-II to LC3-I, a hallmark of autophagy induction, in 2-treated cells from exposure times of 8h onwards»