Info
| ID | 3860 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 6} |
| Abbreviation | Ru1 |
| SMILES | c1c[nH]cn1.c1c[nH]cn1.c1c[nH]cn1.c1c[nH]cn1.c1ccc2nc3c4cccnc4c4ncccc4c3nc2c1 |
TUCAN
C30H26N12Ru/(1-28)(2-34)(3-53)(4-29)(5-31)(6-38)(7-30)(8-32)(9-39)(10-40)(11-33)(12-43)(13-41)(14-54)(15-44)(16-37)(17-55)(18-27)(19-42)(20-45)(21-56)(22-46)(23-59)(24-60)(25-61)(26-62)(27-28)(27-37)(28-36)(29-30)(29-47)(30-33)(31-32)(31-35)(32-43)(33-34)(34-51)(35-48)(35-52)(36-49)(36-50)(37-66)(38-40)(38-59)(39-41)(39-60)(40-64)(41-65)(42-44)(42-67)(43-58)(44-61)(45-46)(45-68)(46-62)(47-51)(47-63)(48-49)(48-57)(49-63)(50-52)(50-66)(51-57)(52-58)(53-59)(53-64)(54-60)(54-65)(55-61)(55-67)(56-62)(56-68)(63-69)(64-69)(65-69)(66-69)(67-69)(68-69)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 21 | — | 10.18632/oncotarget.13032 | 2016 |
| NCI-H460 | 23 | — | 10.18632/oncotarget.13032 | 2016 |
| HepG2 | 26 | — | 10.18632/oncotarget.13032 | 2016 |
| HeLa | 40 | — | 10.18632/oncotarget.13032 | 2016 |
| MCF-7 | 46 | — | 10.18632/oncotarget.13032 | 2016 |
| HBE | 1.8e+02 | — | 10.18632/oncotarget.13032 | 2016 |
🧬 Cell Death Types (2)
Apoptosis
high
«it was found that the ruthenium (II) imidazole complex [Ru(Im)4(dppz)]2+ (Ru1) could induce significant growth inhibition and apoptosis in A549 and NCI-H460 cells.»
Autophagy
high
«it was reported for the first time that Ru1 induced an autophagic response in A549 and NCI-H460 cells as evidenced by the formation of autophagosomes, acidic vesicular organelles (AVOs), and the up-re...»