Info
| ID | 3833 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 6} |
| Abbreviation | RMC4 |
| SMILES | Cn1ccnc1.Cn1ccnc1.Cn1ccnc1.Cn1ccnc1.c1ccc2nc3c4cccnc4c4ncccc4c3nc2c1 |
TUCAN
C34H34N12Ru/(1-65)(2-37)(3-42)(4-45)(5-45)(6-51)(7-50)(8-36)(9-39)(10-66)(11-45)(12-53)(13-38)(14-40)(15-67)(16-52)(17-46)(18-46)(19-41)(20-55)(21-54)(22-56)(23-46)(24-58)(25-47)(26-57)(27-68)(28-49)(29-47)(30-35)(31-47)(32-48)(33-48)(34-48)(35-37)(35-49)(36-38)(36-59)(37-44)(38-41)(39-40)(39-43)(40-55)(41-42)(42-63)(43-60)(43-64)(44-61)(44-62)(45-71)(46-72)(47-73)(48-74)(49-78)(50-51)(50-76)(51-71)(52-53)(52-77)(53-72)(54-56)(54-79)(55-70)(56-73)(57-58)(57-80)(58-74)(59-63)(59-75)(60-61)(60-69)(61-75)(62-64)(62-78)(63-69)(64-70)(65-71)(65-76)(66-72)(66-77)(67-73)(67-79)(68-74)(68-80)(75-81)(76-81)(77-81)(78-81)(79-81)(80-81)
Measurements (11)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A375 | 38 | — | 10.1016/j.biochi.2011.07.025 | 2012 |
| HepG2 | 42 | — | 10.1016/j.biochi.2011.07.025 | 2012 |
| A549 | 42 | — | 10.1016/j.biochi.2011.07.025 | 2012 |
| HepG2 | 43 | — | 10.18632/oncotarget.13032 | 2016 |
| A549 | 47 | — | 10.18632/oncotarget.13032 | 2016 |
| NCI-H460 | 51 | — | 10.18632/oncotarget.13032 | 2016 |
| HeLa | 53 | — | 10.1016/j.biochi.2011.07.025 | 2012 |
| HeLa | 63 | — | 10.18632/oncotarget.13032 | 2016 |
| MCF-7 | 63 | — | 10.18632/oncotarget.13032 | 2016 |
| MCF-7 | 69 | — | 10.1016/j.biochi.2011.07.025 | 2012 |
| HBE | 1.9e+02 | — | 10.18632/oncotarget.13032 | 2016 |
🧬 Cell Death Types (2)
Apoptosis
high
«it was found that the ruthenium (II) imidazole complex [Ru(Im)4(dppz)]2+ (Ru1) could induce significant growth inhibition and apoptosis in A549 and NCI-H460 cells.»
Autophagy
high
«it was reported for the first time that Ru1 induced an autophagic response in A549 and NCI-H460 cells as evidenced by the formation of autophagosomes, acidic vesicular organelles (AVOs), and the up-re...»