Info
| ID | 381 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"O": 1, "P": 2, "N": 2} |
| Abbreviation | 2 |
| SMILES | CC(C)=CCC1=C([O-])C(=O)c2ccccc2C1=O.c1ccc(P(CP(c2ccccc2)c2ccccc2)c2ccccc2)cc1.c1cnc2c(c1)ccc1cccnc12 |
TUCAN
C52H43N2O3P2Ru/(1-46)(2-56)(3-53)(4-47)(5-50)(6-54)(7-48)(8-73)(9-77)(10-77)(11-51)(12-62)(13-66)(14-84)(15-49)(16-57)(17-55)(18-69)(19-58)(20-59)(21-60)(22-61)(23-64)(24-44)(25-68)(26-70)(27-44)(28-63)(29-74)(30-65)(31-95)(32-72)(33-67)(34-76)(35-95)(36-75)(37-85)(38-71)(39-44)(40-45)(41-45)(42-45)(43-52)(44-80)(45-80)(46-53)(46-91)(47-49)(47-78)(48-54)(48-91)(49-84)(50-73)(50-78)(51-77)(51-80)(52-71)(52-81)(53-56)(54-56)(55-59)(55-62)(57-74)(57-85)(58-60)(58-62)(59-92)(60-92)(61-64)(61-93)(63-65)(63-93)(64-66)(65-66)(67-69)(67-72)(68-70)(68-82)(69-75)(70-71)(72-94)(73-83)(74-83)(75-76)(76-94)(77-79)(78-86)(79-88)(79-90)(81-82)(81-89)(82-90)(83-87)(84-96)(85-97)(86-87)(86-96)(87-97)(88-89)(88-99)(89-98)(90-100)(91-101)(92-101)(93-102)(94-102)(95-101)(95-102)(96-103)(97-103)(101-103)(102-103)
Measurements (9)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| DU-145 | 0.8 | — | 10.3389/fonc.2021.682968 | 2021 |
| A375 | 0.9 | — | 10.3389/fonc.2021.682968 | 2021 |
| PC-3 | 1.1 | — | 10.3389/fonc.2021.682968 | 2021 |
| Caco-2 | 1.2 | — | 10.3389/fonc.2021.682968 | 2021 |
| HepG2 | 1.5 | — | 10.3389/fonc.2021.682968 | 2021 |
| MDA-MB-231 | 2 | — | 10.3389/fonc.2021.682968 | 2021 |
| FGH | 2.5 | — | 10.3389/fonc.2021.682968 | 2021 |
| A549 | 2.6 | — | 10.3389/fonc.2021.682968 | 2021 |
| PNT2 | 6.8 | — | 10.3389/fonc.2021.682968 | 2021 |
🧬 Cell Death Types (1)
Apoptosis
high
«The mechanism studies suggest that complex (2) stimulate the overproduction of reactive oxygen species (ROS) and triggers caspase-dependent apoptosis as a result of changes in expression of several ge...»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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