Info
| ID | 380 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"O": 1, "N": 2, "P": 2} |
| Abbreviation | 1 |
| SMILES | CC(C)=CCC1=C([O-])C(=O)c2ccccc2C1=O.c1ccc(-c2ccccn2)nc1.c1ccc(P(CP(c2ccccc2)c2ccccc2)c2ccccc2)cc1 |
TUCAN
C50H43N2O3P2Ru/(1-53)(2-52)(3-47)(4-48)(5-55)(6-46)(7-49)(8-56)(9-82)(10-83)(11-50)(12-57)(13-59)(14-51)(15-44)(16-44)(17-58)(18-63)(19-93)(20-64)(21-62)(22-93)(23-77)(24-61)(25-54)(26-77)(27-74)(28-67)(29-69)(30-65)(31-66)(32-70)(33-72)(34-71)(35-76)(36-68)(37-73)(38-44)(39-75)(40-60)(41-45)(42-45)(43-45)(44-79)(45-79)(46-47)(46-50)(47-89)(48-49)(48-89)(49-50)(51-77)(51-79)(52-53)(52-82)(53-72)(54-61)(54-80)(55-56)(55-90)(56-57)(57-58)(58-63)(59-62)(59-67)(60-61)(60-75)(62-64)(63-90)(64-91)(65-67)(65-91)(66-69)(66-92)(68-69)(68-70)(70-71)(71-92)(72-84)(73-74)(73-76)(74-83)(75-81)(76-85)(77-78)(78-86)(78-87)(80-81)(80-88)(81-86)(82-94)(83-95)(84-85)(84-94)(85-95)(86-97)(87-88)(87-98)(88-96)(89-99)(90-99)(91-100)(92-100)(93-99)(93-100)(94-101)(95-101)(99-101)(100-101)
Measurements (9)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| DU-145 | 0.9 | — | 10.3389/fonc.2021.682968 | 2021 |
| PC-3 | 1.3 | — | 10.3389/fonc.2021.682968 | 2021 |
| HepG2 | 1.7 | — | 10.3389/fonc.2021.682968 | 2021 |
| Caco-2 | 2 | — | 10.3389/fonc.2021.682968 | 2021 |
| MDA-MB-231 | 2.1 | — | 10.3389/fonc.2021.682968 | 2021 |
| A375 | 2.5 | — | 10.3389/fonc.2021.682968 | 2021 |
| FGH | 3.1 | — | 10.3389/fonc.2021.682968 | 2021 |
| A549 | 3.3 | — | 10.3389/fonc.2021.682968 | 2021 |
| PNT2 | 5.9 | — | 10.3389/fonc.2021.682968 | 2021 |
🧬 Cell Death Types (1)
Apoptosis
high
«The mechanism studies suggest that complex (2) stimulate the overproduction of reactive oxygen species (ROS) and triggers caspase-dependent apoptosis as a result of changes in expression of several ge...»