Info
| ID | 3767 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 1} |
| Abbreviation | 3 |
| SMILES | Cc1ccccc1.O=C(CCc1cccnc1)OCCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F.[Cl-].[Cl-] |
TUCAN
C25Cl2F17NO2Ru/(1-12)(2-10)(2-13)(3-5)(3-7)(4-5)(4-12)(6-7)(6-12)(8-9)(8-13)(9-14)(10-17)(11-16)(11-21)(13-15)(14-26)(15-26)(16-28)(17-27)(17-28)(18-19)(18-24)(18-31)(18-32)(19-20)(19-33)(19-34)(20-22)(20-35)(20-36)(21-24)(21-38)(21-40)(22-23)(22-37)(22-39)(23-25)(23-41)(23-42)(24-29)(24-30)(25-43)(25-44)(25-45)
Measurements (2)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A2780 | 87 | — | 10.1021/jm5002748 | 2014 |
| HEK293 | — | — | 10.1021/jm5002748 | 2014 |
🧬 Cell Death Types (1)
Apoptosis
medium
«As reflected by the number of subdiploid cells (Figure 4 and Table 4), a moderate effect on apoptosis induction was observed at the 50 μM dose.»