Info
| ID | 3760 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 4} |
| Abbreviation | 5 |
| SMILES | Ic1ccc(-c2nc3c4cccnc4c4ncccc4c3[nH]2)cc1.[Cl-].c1ccccc1 |
TUCAN
C25H17IN4Ru/(1-18)(2-28)(3-25)(4-27)(5-19)(6-23)(7-35)(8-20)(9-21)(10-30)(11-26)(12-29)(13-22)(14-31)(15-36)(16-24)(17-44)(18-19)(18-20)(19-21)(20-22)(21-24)(22-24)(23-27)(23-42)(25-26)(25-32)(26-35)(27-34)(28-29)(28-36)(29-33)(30-31)(30-42)(31-34)(32-37)(32-38)(33-39)(33-40)(34-41)(35-46)(36-43)(37-39)(37-46)(38-40)(38-45)(39-43)(40-44)(41-44)(41-45)(42-48)(45-47)(46-47)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MDA-MB-231 | 59 | — | 10.1021/acs.organomet.5b00820 | 2015 |
| HepG2 | 1.8e+02 | — | 10.1021/acs.organomet.5b00820 | 2015 |
| MCF-7 | — | — | 10.1021/acs.organomet.5b00820 | 2015 |
🧬 Cell Death Types (1)
Apoptosis
high
«the exposure of MDA-MB-231 cells to 10, 20, and 40 μM 3 for 24 h triggered a significant increase in the number of cells under S-phase arrest and in the induction of cell apoptosis.»