Info
| ID | 3757 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 4} |
| Abbreviation | 1 |
| SMILES | [Cl-].c1ccc(-c2nc3c4cccnc4c4ncccc4c3[nH]2)cc1.c1ccccc1 |
TUCAN
C25H18N4Ru/(1-29)(2-25)(3-26)(4-19)(5-20)(6-21)(7-31)(8-37)(9-22)(10-23)(11-28)(12-27)(13-30)(14-24)(15-38)(16-32)(17-33)(18-45)(19-20)(19-21)(20-22)(21-23)(22-24)(23-24)(25-27)(25-34)(26-28)(26-38)(27-37)(28-35)(29-30)(29-33)(30-36)(31-32)(31-33)(32-36)(34-39)(34-40)(35-41)(35-42)(36-43)(37-46)(38-44)(39-42)(39-47)(40-41)(40-46)(41-44)(42-45)(43-45)(43-47)(46-48)(47-48)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HepG2 | 2.9e+02 | — | 10.1021/acs.organomet.5b00820 | 2015 |
| MDA-MB-231 | — | — | 10.1021/acs.organomet.5b00820 | 2015 |
| MCF-7 | — | — | 10.1021/acs.organomet.5b00820 | 2015 |
🧬 Cell Death Types (1)
Apoptosis
high
«the exposure of MDA-MB-231 cells to 10, 20, and 40 μM 3 for 24 h triggered a significant increase in the number of cells under S-phase arrest and in the induction of cell apoptosis.»