Info
| ID | 3719 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 7} |
| Abbreviation | 4 |
| SMILES | CC(C)(C)c1ccc(-n2c(-c3ccc(C(F)(F)F)cc3)nc3c4cccnc4c4ncccc4c32)cc1.[c-]1cccc2ccc3cccnc3c12.c1cnc2c(c1)ccc1cccnc12 |
TUCAN
C55H39F3N7Ru/(1-40)(2-50)(3-40)(4-40)(5-61)(6-65)(7-51)(8-47)(9-80)(10-45)(11-46)(12-52)(13-57)(14-48)(15-59)(16-55)(17-82)(18-83)(19-58)(20-84)(21-49)(22-64)(23-41)(24-41)(25-41)(26-42)(27-56)(28-62)(29-54)(30-44)(31-66)(32-67)(33-81)(34-68)(35-63)(36-53)(37-60)(38-42)(39-42)(40-79)(41-79)(42-79)(43-49)(43-75)(44-58)(44-82)(45-46)(45-80)(46-70)(47-50)(47-77)(48-67)(48-70)(49-59)(50-69)(51-52)(51-87)(52-71)(53-54)(53-81)(54-73)(55-57)(55-84)(56-64)(56-71)(57-72)(58-69)(59-65)(60-66)(60-78)(61-62)(61-76)(62-74)(63-68)(63-74)(64-87)(65-77)(66-83)(67-78)(68-76)(69-92)(70-85)(71-79)(72-88)(72-91)(73-89)(73-90)(74-94)(75-77)(75-92)(76-93)(78-86)(80-97)(81-99)(82-100)(83-98)(84-95)(85-86)(85-97)(86-98)(87-96)(88-90)(88-96)(89-91)(89-99)(90-101)(91-95)(92-100)(93-96)(93-101)(94-102)(94-103)(94-104)(97-105)(98-105)(99-105)(100-105)(101-105)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549cisR | 0.8 | — | 10.1038/srep19449 | 2016 |
| A549 | 1 | — | 10.1038/srep19449 | 2016 |
| A549R MCTSs | 1.8 | — | 10.1038/srep19449 | 2016 |
| HeLa | 2.4 | — | 10.1038/srep19449 | 2016 |
| LO2 | 6.7 | — | 10.1038/srep19449 | 2016 |
🧬 Cell Death Types (1)
Apoptosis
high
«A double-staining Annexin V/PI apoptosis kit and flow cytometry were used to investigate the nature of A549R cell death induced by complex 4. The results are shown in Fig. 7b. At a concentration as lo...»