Info
| ID | 3718 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 8} |
| Abbreviation | 3 |
| SMILES | CC(C)(C)c1ccc(-n2c(-c3ccc(C(F)(F)F)cc3)nc3c4cccnc4c4ncccc4c32)cc1.c1cnc2c(c1)ccc1cccnc12.c1cnc2c(c1)ccc1cccnc12 |
TUCAN
C54H39F3N8Ru/(1-40)(2-77)(3-40)(4-40)(5-41)(6-80)(7-50)(8-46)(9-78)(10-47)(11-44)(12-54)(13-81)(14-43)(15-51)(16-55)(17-45)(18-48)(19-52)(20-41)(21-79)(22-58)(23-53)(24-66)(25-49)(26-59)(27-56)(28-57)(29-41)(30-42)(31-61)(32-82)(33-64)(34-42)(35-42)(36-65)(37-63)(38-62)(39-60)(40-76)(41-76)(42-76)(43-58)(43-67)(44-46)(44-67)(45-47)(45-68)(46-77)(47-78)(48-49)(48-87)(49-69)(50-54)(50-72)(51-52)(51-81)(52-71)(53-59)(53-70)(54-80)(55-62)(55-68)(56-57)(56-79)(57-74)(58-74)(59-73)(60-61)(60-82)(61-75)(62-75)(63-66)(63-69)(64-65)(64-73)(65-70)(66-87)(67-83)(68-84)(69-76)(70-92)(71-88)(71-91)(72-89)(72-90)(73-93)(74-85)(75-86)(77-96)(78-97)(79-98)(80-94)(81-101)(82-100)(83-85)(83-96)(84-86)(84-97)(85-98)(86-100)(87-95)(88-89)(88-99)(89-95)(90-91)(90-94)(91-101)(92-95)(92-99)(93-102)(93-103)(93-104)(96-105)(97-105)(98-105)(99-105)(100-105)(101-105)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 22 | — | 10.1038/srep19449 | 2016 |
| A549 | 29 | — | 10.1038/srep19449 | 2016 |
| A549cisR | 32 | — | 10.1038/srep19449 | 2016 |
| LO2 | 46 | — | 10.1038/srep19449 | 2016 |
| A549R MCTSs | 61 | — | 10.1038/srep19449 | 2016 |
🧬 Cell Death Types (1)
Apoptosis
high
«A double-staining Annexin V/PI apoptosis kit and flow cytometry were used to investigate the nature of A549R cell death induced by complex 4. The results are shown in Fig. 7b. At a concentration as lo...»