Info
| ID | 3657 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 1, "O": 1} |
| Abbreviation | L4-Ru |
| SMILES | Cc1ccc(C(C)C)cc1.O=c1cc(-c2ccccc2)oc2cc(OCCCCN3CCCCC3)cc([O-])c12.[Cl-] |
TUCAN
C34H40NO4Ru/(1-69)(2-69)(3-58)(4-45)(5-65)(6-47)(7-41)(8-67)(9-57)(10-53)(11-59)(12-56)(13-44)(14-59)(15-51)(16-57)(17-67)(18-68)(19-52)(20-54)(21-66)(22-60)(23-66)(24-50)(25-55)(26-46)(27-58)(28-68)(29-60)(30-56)(31-42)(32-42)(33-41)(34-41)(35-42)(36-43)(37-48)(38-43)(39-49)(40-43)(41-61)(42-65)(43-65)(44-70)(44-72)(45-47)(45-61)(46-50)(46-55)(47-62)(48-49)(48-62)(49-61)(50-51)(51-64)(52-72)(52-73)(53-71)(53-74)(54-55)(54-64)(56-58)(56-69)(57-59)(57-67)(58-66)(59-60)(60-68)(62-65)(63-70)(63-73)(63-74)(64-71)(66-75)(67-75)(68-75)(69-78)(70-76)(71-79)(72-78)(73-79)(74-77)(78-80)(79-80)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A2780cisR | 8.4 | — | 10.3390/pharmaceutics13101540 | 2021 |
| A2780 | 15 | — | 10.3390/pharmaceutics13101540 | 2021 |
| SW480 | 28 | — | 10.3390/pharmaceutics13101540 | 2021 |
| A549 | 31 | — | 10.3390/pharmaceutics13101540 | 2021 |
| IMR-90 | 54 | — | 10.3390/pharmaceutics13101540 | 2021 |
🧬 Cell Death Types (1)
Apoptosis
high
«ROS generation leads to oxidative stress and can trigger apoptosis. In order to confirm if apoptosis is the mechanism of cell death caused by the compounds under study, apoptosis induction was studied...»