Info
| ID | 3631 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 1} |
| Abbreviation | Ru(pip) |
| SMILES | COc1cc(/C=C/C(=O)N2CCC=CC2=O)cc(OC)c1OC.Cc1ccc(C(C)C)cc1.[Cl-] |
TUCAN
C27ClNO5Ru/(1-15)(2-15)(3-16)(4-12)(4-18)(5-8)(5-10)(6-7)(6-16)(7-17)(8-19)(9-14)(9-17)(10-26)(11-18)(11-23)(12-27)(13-18)(13-24)(14-16)(15-17)(19-28)(20-32)(21-31)(22-33)(23-25)(23-32)(24-25)(24-33)(25-31)(26-28)(26-30)(27-28)(27-29)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MCF-7 | 48 | — | 10.1039/d3dt02940a | 2023 |
| HEK293 | 56 | — | 10.1039/d3dt02940a | 2023 |
| THP-1 | 73 | — | 10.1039/d3dt02940a | 2023 |
| HepG2 | — | — | 10.1039/d3dt02940a | 2023 |
🧬 Cell Death Types (1)
Apoptosis
high
«While Ru(pip) exhibits both necrotic and apoptotic modes of cell death, PL-Ru(pip)@MSNRs preferably induce the apoptotic mode of cell death in MCF-7 and THP-1 cells.»