Info
| ID | 3630 |
| Metal | Ru |
| Oxidation state | 3 |
| Charge | 0 |
| Donor atoms | {"N": 6} |
| Abbreviation | Complex 3 |
| SMILES | CCCCc1c(C)nn(-c2cc(C)c3c(n2)nn2c(C)c(CCCC)c(C)nc32)c1C.O.[Cl-].[Cl-].[Cl-] |
TUCAN
C25H34N6Ru/(1-48)(2-42)(3-38)(4-36)(5-44)(6-45)(7-37)(8-39)(9-39)(10-35)(11-37)(12-36)(13-47)(14-44)(15-35)(16-39)(17-40)(18-40)(19-46)(20-43)(21-36)(22-38)(23-38)(24-37)(25-48)(26-46)(27-47)(28-40)(29-35)(30-45)(31-43)(32-41)(33-41)(34-41)(35-45)(36-56)(37-53)(38-52)(39-55)(40-54)(41-48)(42-52)(42-59)(43-47)(43-49)(44-46)(44-50)(45-46)(47-48)(49-53)(49-55)(50-54)(50-56)(51-52)(51-57)(51-58)(53-65)(54-60)(55-62)(56-63)(57-60)(57-63)(58-61)(58-64)(59-62)(59-64)(61-63)(62-65)(64-66)(65-66)
Measurements (7)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| SK-OV-3 | 28 | — | 10.1039/d1dt02765d | 2022 |
| MGC-803 | 29 | — | 10.1039/d1dt02765d | 2022 |
| HeLa | 31 | — | 10.1039/d1dt02765d | 2022 |
| T24 | 32 | — | 10.1039/d1dt02765d | 2022 |
| A549 | 35 | — | 10.1039/d1dt02765d | 2022 |
| NCI-H460 | 36 | — | 10.1039/d1dt02765d | 2022 |
| HL-7702 | 37 | — | 10.1039/d1dt02765d | 2022 |
🧬 Cell Death Types (1)
Apoptosis
high
«induced apoptosis by elevating the levels of intracellular ROS (reactive oxygen species) and free calcium (Ca2+), and reduced mitochondrial membrane potential (ΔΨ). It also activated the caspase casca...»