Info
| ID | 3629 |
| Metal | Ru |
| Oxidation state | 3 |
| Charge | 0 |
| Donor atoms | {"N": 6} |
| Abbreviation | Complex 2 |
| SMILES | Cc1cc(C)n2nc3nc(-n4nc(C)cc4C)cc(C)c3c2n1.O.[Cl-].[Cl-].[Cl-] |
TUCAN
C17H18N6Ru/(1-20)(2-23)(3-21)(4-19)(5-19)(6-22)(7-19)(8-24)(9-25)(10-22)(11-20)(12-23)(13-21)(14-23)(15-26)(16-20)(17-21)(18-22)(19-28)(20-29)(21-31)(22-30)(23-32)(24-30)(24-31)(25-28)(25-35)(26-29)(26-32)(27-28)(27-33)(27-34)(29-38)(30-39)(31-37)(32-36)(33-36)(33-38)(34-40)(34-41)(35-39)(35-40)(37-39)(38-41)(40-42)(41-42)
Measurements (7)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HL-7702 | 24 | — | 10.1039/d1dt02765d | 2022 |
| T24 | 24 | — | 10.1039/d1dt02765d | 2022 |
| HeLa | 26 | — | 10.1039/d1dt02765d | 2022 |
| MGC-803 | 28 | — | 10.1039/d1dt02765d | 2022 |
| NCI-H460 | 30 | — | 10.1039/d1dt02765d | 2022 |
| A549 | 31 | — | 10.1039/d1dt02765d | 2022 |
| SK-OV-3 | 33 | — | 10.1039/d1dt02765d | 2022 |
🧬 Cell Death Types (1)
Apoptosis
high
«induced apoptosis by elevating the levels of intracellular ROS (reactive oxygen species) and free calcium (Ca2+), and reduced mitochondrial membrane potential (ΔΨ). It also activated the caspase casca...»