Info
| ID | 3628 |
| Metal | Ru |
| Oxidation state | 3 |
| Charge | 0 |
| Donor atoms | {"N": 6} |
| Abbreviation | Complex 1 |
| SMILES | Cc1cc(-c2ccccc2)n2nc3nc(-n4nc(C)cc4-c4ccccc4)cc(C)c3c2n1.O.[Cl-].[Cl-].[Cl-] |
TUCAN
C27H22N6Ru/(1-24)(2-25)(3-33)(4-34)(5-25)(6-25)(7-23)(8-23)(9-28)(10-23)(11-26)(12-30)(13-27)(14-24)(15-38)(16-24)(17-35)(18-32)(19-36)(20-37)(21-31)(22-29)(23-40)(24-44)(25-46)(26-27)(26-28)(27-42)(28-29)(29-31)(30-40)(30-48)(31-42)(32-34)(32-41)(33-44)(33-45)(34-35)(35-36)(36-37)(37-41)(38-43)(38-46)(39-40)(39-47)(39-49)(41-43)(42-45)(43-52)(44-51)(45-53)(46-50)(47-50)(47-52)(48-53)(48-54)(49-54)(49-55)(51-53)(52-55)(54-56)(55-56)
Measurements (7)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| SK-OV-3 | 9.7 | — | 10.1039/d1dt02765d | 2022 |
| A549 | 13 | — | 10.1039/d1dt02765d | 2022 |
| T24 | 14 | — | 10.1039/d1dt02765d | 2022 |
| MGC-803 | 20 | — | 10.1039/d1dt02765d | 2022 |
| HeLa | 20 | — | 10.1039/d1dt02765d | 2022 |
| HL-7702 | 20 | — | 10.1039/d1dt02765d | 2022 |
| NCI-H460 | 21 | — | 10.1039/d1dt02765d | 2022 |
🧬 Cell Death Types (1)
Apoptosis
high
«induced apoptosis by elevating the levels of intracellular ROS (reactive oxygen species) and free calcium (Ca2+), and reduced mitochondrial membrane potential (ΔΨ). It also activated the caspase casca...»