Info
| ID | 359 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"O": 1, "N": 2, "P": 1} |
| Abbreviation | Ru9 |
| SMILES | OC[c-]1cccc1.OCc1ccnc(-c2cc(CO)ccn2)c1.c1ccc(P(c2ccccc2)c2ccccc2)cc1 |
TUCAN
C36H34N2O3PRu/(1-35)(2-40)(3-65)(4-66)(5-36)(6-56)(7-38)(8-43)(9-47)(10-49)(11-39)(12-41)(13-46)(14-42)(15-51)(16-57)(17-66)(18-37)(19-65)(20-48)(21-52)(22-50)(23-54)(24-44)(25-53)(26-61)(27-62)(28-45)(29-55)(30-67)(31-67)(32-73)(33-74)(34-75)(35-40)(35-68)(36-37)(36-56)(37-60)(38-41)(38-68)(39-42)(39-69)(40-43)(41-43)(42-47)(44-59)(44-63)(45-58)(45-61)(46-51)(46-69)(47-51)(48-52)(48-70)(49-52)(49-53)(50-53)(50-70)(54-58)(54-64)(55-56)(55-60)(57-59)(57-62)(58-65)(59-66)(60-67)(61-71)(62-72)(63-64)(63-72)(64-71)(65-73)(66-74)(67-75)(68-76)(69-76)(70-76)(71-77)(72-77)(74-77)(75-77)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MCF-7 | 6.1 | — | 10.1016/j.jinorgbio.2023.11243... | 2024 |
| MDA-MB-231 | 21 | — | 10.1016/j.jinorgbio.2023.11243... | 2024 |
| RKO | 45 | — | 10.3390/pharmaceutics14061293 | 2022 |
| SW480 | — | — | 10.3390/pharmaceutics14061293 | 2022 |
| V79 | — | — | 10.1016/j.jinorgbio.2023.11243... | 2024 |
🧬 Cell Death Types (1)
Apoptosis
high
«Based on the results obtained with this assay, we conclude that these compounds induced cell death by apoptosis.»