Info
| ID | 358 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"O": 1, "N": 2, "P": 1} |
| Abbreviation | Ru8 |
| SMILES | O=C[c-]1cccc1.OCc1ccnc(-c2cc(CO)ccn2)c1.c1ccc(P(c2ccccc2)c2ccccc2)cc1 |
TUCAN
C36H32N2O3PRu/(1-33)(2-36)(3-64)(4-35)(5-37)(6-41)(7-46)(8-48)(9-39)(10-38)(11-40)(12-45)(13-50)(14-42)(15-64)(16-65)(17-65)(18-47)(19-51)(20-49)(21-44)(22-53)(23-52)(24-59)(25-60)(26-43)(27-34)(28-54)(29-63)(30-55)(31-72)(32-73)(33-36)(33-41)(34-35)(34-55)(35-57)(36-66)(37-38)(37-66)(38-41)(39-40)(39-67)(40-46)(42-56)(42-59)(43-58)(43-60)(44-56)(44-61)(45-50)(45-67)(46-50)(47-51)(47-68)(48-51)(48-52)(49-52)(49-68)(53-58)(53-62)(54-55)(54-57)(56-64)(57-63)(58-65)(59-69)(60-70)(61-62)(61-69)(62-70)(63-71)(64-72)(65-73)(66-74)(67-74)(68-74)(69-75)(70-75)(72-75)(73-75)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MCF-7 | 18 | — | 10.1016/j.jinorgbio.2023.11243... | 2024 |
| MDA-MB-231 | 36 | — | 10.1016/j.jinorgbio.2023.11243... | 2024 |
| RKO | — | — | 10.3390/pharmaceutics14061293 | 2022 |
| SW480 | — | — | 10.3390/pharmaceutics14061293 | 2022 |
| V79 | — | — | 10.1016/j.jinorgbio.2023.11243... | 2024 |
🧬 Cell Death Types (1)
Apoptosis
high
«Based on the results obtained with this assay, we conclude that these compounds induced cell death by apoptosis.»