Info
| ID | 3560 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 4} |
| Abbreviation | RAPTMP(C) |
| SMILES | COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC.Cc1ccc(C(C)C)cc1.[Cl-].[Cl-] |
TUCAN
C24H32N4O3Ru/(1-36)(2-38)(3-33)(4-33)(5-34)(6-33)(7-35)(8-35)(9-47)(10-37)(11-34)(12-40)(13-35)(14-34)(15-48)(16-42)(17-42)(18-39)(19-52)(20-52)(21-52)(22-41)(23-51)(24-51)(25-53)(26-53)(27-51)(28-53)(29-57)(30-57)(31-58)(32-58)(33-47)(34-43)(35-47)(36-37)(36-43)(37-44)(38-40)(38-43)(39-46)(39-54)(40-44)(41-46)(41-56)(42-45)(42-46)(44-47)(45-48)(45-49)(48-59)(49-57)(49-60)(50-58)(50-59)(50-60)(51-61)(52-62)(53-63)(54-55)(54-62)(55-56)(55-61)(56-63)(59-64)(60-64)(62-64)(63-64)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HepG2 | 49 | — | 10.1039/d0nj03664a | 2020 |
| A549 | — | — | 10.1039/d0nj03664a | 2020 |
| MCF-7 | — | — | 10.1039/d0nj03664a | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«The results obtained from AO/EB staining assay indicate that the complex and nanoformulation induce both apoptotic and necrotic mode of cell death, but mainly through apoptosis.»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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