Info
| ID | 356 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 2, "O": 1, "P": 1} |
| Abbreviation | Ru6 |
| SMILES | Cc1ccnc(-c2cc(C)ccn2)c1.O=C[c-]1cccc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1 |
TUCAN
C36H32N2OPRu/(1-65)(2-37)(3-44)(4-35)(5-48)(6-42)(7-43)(8-38)(9-50)(10-33)(11-33)(12-56)(13-33)(14-47)(15-49)(16-52)(17-36)(18-61)(19-40)(20-39)(21-51)(22-53)(23-54)(24-45)(25-55)(26-41)(27-34)(28-34)(29-57)(30-62)(31-46)(32-34)(33-58)(34-59)(35-37)(35-66)(36-39)(36-60)(37-42)(38-44)(38-66)(39-45)(40-58)(40-61)(41-45)(41-60)(42-44)(43-48)(43-50)(46-59)(46-62)(47-48)(47-67)(49-50)(49-67)(51-53)(51-54)(52-53)(52-68)(54-55)(55-68)(56-58)(56-63)(57-59)(57-64)(60-65)(61-69)(62-70)(63-64)(63-69)(64-70)(65-71)(66-72)(67-72)(68-72)(69-73)(70-73)(72-73)
Measurements (18)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MCF-7 | 0.09 | — | 10.1016/j.jinorgbio.2023.11243... | 2024 |
| MDA-MB-231 | 0.63 | — | 10.1016/j.jinorgbio.2023.11243... | 2024 |
| RKO | 1.1 | — | 10.3390/pharmaceutics14061293 | 2022 |
| EA.hy926 | 4.3 | — | 10.1016/j.phrs.2024.107353 | 2024 |
| EA.hy926 | 5 | — | 10.1016/j.phrs.2024.107353 | 2024 |
| SW480 | 5.4 | — | 10.3390/pharmaceutics14061293 | 2022 |
| V79 | 6.5 | — | 10.1016/j.jinorgbio.2023.11243... | 2024 |
| NCM460 | 8.5 | — | 10.3390/pharmaceutics14061293 | 2022 |
| EA.hy926 | 10 | — | 10.1016/j.phrs.2024.107353 | 2024 |
| H9c2 | 12 | — | 10.1016/j.phrs.2024.107353 | 2024 |
| HdFa | 17 | — | 10.1016/j.phrs.2024.107353 | 2024 |
| HSAEC | 29 | — | 10.1016/j.phrs.2024.107353 | 2024 |
| HdFa | 30 | — | 10.1016/j.phrs.2024.107353 | 2024 |
| HSAEC | 43 | — | 10.1016/j.phrs.2024.107353 | 2024 |
| H9c2 | 45 | — | 10.1016/j.phrs.2024.107353 | 2024 |
| H9c2 | 52 | — | 10.1016/j.phrs.2024.107353 | 2024 |
| HdFa | — | — | 10.1016/j.phrs.2024.107353 | 2024 |
| HSAEC | — | — | 10.1016/j.phrs.2024.107353 | 2024 |
🧬 Cell Death Types (1)
Apoptosis
high
«Based on the results obtained with this assay, we conclude that these compounds induced cell death by apoptosis.»