Info
| ID | 3559 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"P": 2} |
| Abbreviation | 2 |
| SMILES | C=C(P(c1ccccc1)c1ccccc1)P(c1ccccc1)c1ccccc1.Cc1ccc(C(C)C)cc1.[Cl-] |
TUCAN
C36H36P2Ru/(1-45)(2-39)(3-41)(4-39)(5-54)(6-46)(7-38)(8-39)(9-38)(10-43)(11-47)(12-48)(13-38)(14-42)(15-40)(16-49)(17-51)(18-56)(19-40)(20-44)(21-50)(22-52)(23-55)(24-57)(25-61)(26-60)(27-58)(28-37)(29-37)(30-63)(31-53)(32-67)(33-40)(34-59)(35-62)(36-64)(37-72)(38-65)(39-67)(40-67)(41-42)(41-65)(42-66)(43-45)(43-68)(44-46)(44-68)(45-47)(46-47)(48-49)(48-50)(49-51)(50-69)(51-52)(52-69)(53-54)(53-66)(54-65)(55-56)(55-70)(56-61)(57-58)(57-61)(58-70)(59-60)(59-71)(60-63)(62-63)(62-64)(64-71)(66-67)(68-73)(69-73)(70-74)(71-74)(72-73)(72-74)(73-75)(74-75)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MCF-7 | 1.5 | — | 10.1021/acs.inorgchem.0c02768 | 2021 |
| A2780 | 1.9 | — | 10.1021/acs.inorgchem.0c02768 | 2021 |
| MDA-MB-231 | 2.6 | — | 10.1021/acs.inorgchem.0c02768 | 2021 |
🧬 Cell Death Types (2)
Apoptosis
high
«leading to a combined cell death mechanism via apoptosis and autophagy (abstract). Also: 'an increase of apoptotic markers was observed, such as chromatin condensation and apoptotic bodies, correspond...»
Autophagy
high
«leading to a combined cell death mechanism via apoptosis and autophagy (abstract). Also: 'Cells exposed to complexes 1 and 2 showed an accumulation of autophagolysosomes characteristic of the inductio...»