Info
| ID | 3558 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"P": 2} |
| Abbreviation | 1 |
| SMILES | C=C(CP(c1ccccc1)c1ccccc1)CP(c1ccccc1)c1ccccc1.Cc1ccc(C(C)C)cc1.[Cl-] |
TUCAN
C38H40P2Ru/(1-47)(2-46)(3-42)(4-45)(5-42)(6-44)(7-52)(8-48)(9-50)(10-44)(11-42)(12-49)(13-54)(14-53)(15-43)(16-59)(17-43)(18-56)(19-73)(20-57)(21-43)(22-55)(23-73)(24-51)(25-62)(26-66)(27-67)(28-74)(29-74)(30-41)(31-61)(32-58)(33-41)(34-64)(35-44)(36-60)(37-72)(38-68)(39-63)(40-65)(41-70)(42-72)(43-72)(44-71)(45-46)(45-71)(46-69)(47-49)(47-52)(48-49)(48-54)(50-51)(50-56)(51-53)(52-75)(53-57)(54-75)(55-58)(55-62)(56-76)(57-76)(58-61)(59-60)(59-69)(60-71)(61-66)(62-77)(63-64)(63-67)(64-65)(65-68)(66-77)(67-78)(68-78)(69-72)(70-73)(70-74)(73-79)(74-80)(75-79)(76-79)(77-80)(78-80)(79-81)(80-81)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MCF-7 | 0.19 | — | 10.1021/acs.inorgchem.0c02768 | 2021 |
| A2780 | 0.32 | — | 10.1021/acs.inorgchem.0c02768 | 2021 |
| MDA-MB-231 | 0.4 | — | 10.1021/acs.inorgchem.0c02768 | 2021 |
🧬 Cell Death Types (2)
Apoptosis
high
«leading to a combined cell death mechanism via apoptosis and autophagy (abstract). Also: 'an increase of apoptotic markers was observed, such as chromatin condensation and apoptotic bodies, correspond...»
Autophagy
high
«leading to a combined cell death mechanism via apoptosis and autophagy (abstract). Also: 'Cells exposed to complexes 1 and 2 showed an accumulation of autophagolysosomes characteristic of the inductio...»