Info
| ID | 355 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"O": 1, "N": 2, "P": 1} |
| Abbreviation | Ru5 |
| SMILES | OC[c-]1cccc1.c1ccc(-c2ccccn2)nc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1 |
TUCAN
C34H30N2OPRu/(1-31)(2-37)(3-38)(4-57)(5-42)(6-55)(7-45)(8-36)(9-33)(10-32)(11-48)(12-40)(13-49)(14-41)(15-34)(16-58)(17-47)(18-39)(19-51)(20-52)(21-53)(22-50)(23-54)(24-46)(25-35)(26-43)(27-61)(28-61)(29-44)(30-67)(31-33)(31-62)(32-33)(32-40)(34-45)(34-57)(35-36)(35-44)(36-56)(37-40)(37-62)(38-41)(38-63)(39-41)(39-47)(42-45)(42-59)(43-44)(43-56)(46-51)(46-52)(47-48)(48-63)(49-51)(49-64)(50-52)(50-64)(53-54)(53-58)(54-55)(55-60)(56-61)(57-65)(58-66)(59-60)(59-65)(60-66)(61-67)(62-68)(63-68)(64-68)(65-69)(66-69)(67-69)(68-69)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MCF-7 | 0.09 | — | 10.1016/j.jinorgbio.2023.11243... | 2024 |
| MDA-MB-231 | 0.87 | — | 10.1016/j.jinorgbio.2023.11243... | 2024 |
| RKO | 1.2 | — | 10.3390/pharmaceutics14061293 | 2022 |
| V79 | 4.8 | — | 10.1016/j.jinorgbio.2023.11243... | 2024 |
| SW480 | 11 | — | 10.3390/pharmaceutics14061293 | 2022 |
| NCM460 | 14 | — | 10.3390/pharmaceutics14061293 | 2022 |
🧬 Cell Death Types (1)
Apoptosis
high
«Based on the results obtained with this assay, we conclude that these compounds induced cell death by apoptosis.»