Info
| ID | 3545 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 4, "S": 1, "P": 2} |
| Abbreviation | 3 |
| SMILES | CN(C)/C([S-])=N/C(=O)c1ccccc1.c1ccc(-c2ccccn2)nc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1 |
TUCAN
C56H49N4OP2RuS/(1-51)(2-50)(3-52)(4-55)(5-54)(6-59)(7-53)(8-94)(9-95)(10-66)(11-62)(12-65)(13-63)(14-61)(15-57)(16-58)(17-56)(18-67)(19-71)(20-68)(21-60)(22-69)(23-72)(24-70)(25-75)(26-73)(27-77)(28-79)(29-76)(30-90)(31-64)(32-87)(33-86)(34-92)(35-85)(36-92)(37-92)(38-88)(39-89)(40-78)(41-80)(42-83)(43-81)(44-74)(45-84)(46-82)(47-93)(48-93)(49-93)(50-51)(50-55)(51-99)(52-53)(52-55)(53-99)(54-56)(54-57)(56-59)(57-100)(58-59)(58-100)(60-61)(60-71)(61-67)(62-64)(62-66)(63-65)(63-90)(64-96)(65-91)(66-94)(67-101)(68-71)(68-101)(69-72)(69-102)(70-72)(70-75)(73-75)(73-102)(74-76)(74-78)(76-77)(77-103)(78-79)(79-103)(80-81)(80-104)(81-82)(82-84)(83-84)(83-104)(85-87)(85-95)(86-89)(86-91)(87-88)(88-97)(89-90)(91-98)(92-106)(93-106)(94-108)(95-109)(96-97)(96-108)(97-109)(98-107)(98-110)(99-111)(100-111)(101-111)(102-112)(103-112)(104-112)(105-106)(105-107)(105-113)(107-114)(108-114)(109-114)(111-114)(112-114)
Measurements (2)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MCF-10A | 8.8 | — | 10.1016/j.jinorgbio.2018.05.01... | 2018 |
| MDA-MB-231 | 9.3 | — | 10.1016/j.jinorgbio.2018.05.01... | 2018 |
🧬 Cell Death Types (1)
Apoptosis
high
«Complex (2) inhibited proliferation, migration, invasion, adhesion, changed morphology and induced apoptosis, DNA damage and nuclear fragmentation of TNBC cells ... Complex (2) was able to induce apop...»