Info
| ID | 3544 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 4, "S": 1, "P": 2} |
| Abbreviation | 2 |
| SMILES | CN(C)/C([S-])=N/C(=O)c1cccs1.c1ccc(-c2ccccn2)nc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1 |
TUCAN
C54H47N4OP2RuS2/(1-49)(2-51)(3-48)(4-50)(5-54)(6-52)(7-55)(8-53)(9-88)(10-89)(11-60)(12-59)(13-81)(14-84)(15-58)(16-57)(17-61)(18-64)(19-62)(20-63)(21-99)(22-82)(23-56)(24-65)(25-72)(26-67)(27-73)(28-74)(29-66)(30-68)(31-70)(32-69)(33-83)(34-85)(35-86)(36-86)(37-86)(38-87)(39-80)(40-87)(41-71)(42-76)(43-79)(44-75)(45-77)(46-78)(47-87)(48-49)(48-93)(49-51)(50-51)(50-55)(52-54)(52-58)(53-54)(53-61)(55-93)(56-57)(56-64)(57-62)(58-94)(59-60)(59-81)(60-88)(61-94)(62-95)(63-64)(63-95)(65-67)(65-96)(66-67)(66-68)(68-72)(69-70)(69-73)(70-71)(71-74)(72-96)(73-97)(74-97)(75-76)(75-77)(76-98)(77-78)(78-79)(79-98)(80-85)(80-89)(81-90)(82-83)(82-99)(83-100)(84-85)(84-91)(86-102)(87-102)(88-104)(89-105)(90-91)(90-104)(91-105)(92-100)(92-103)(92-106)(93-107)(94-107)(95-107)(96-108)(97-108)(98-108)(99-110)(100-110)(101-102)(101-103)(101-109)(103-111)(104-111)(105-111)(107-111)(108-111)(110-111)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| T4-2 | 5 | — | 10.1039/d0qi00502a | 2020 |
| MDA-MB-231 | 8.8 | — | 10.1016/j.jinorgbio.2018.05.01... | 2018 |
| MCF-10A | 15 | — | 10.1016/j.jinorgbio.2018.05.01... | 2018 |
| S1 | 19 | — | 10.1039/d0qi00502a | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«Complex (2) inhibited proliferation, migration, invasion, adhesion, changed morphology and induced apoptosis, DNA damage and nuclear fragmentation of TNBC cells ... Complex (2) was able to induce apop...»