Info
| ID | 3543 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 4, "S": 1, "P": 2} |
| Abbreviation | 1 |
| SMILES | CCCCN(CCCC)/C([S-])=N/C(=O)c1ccccc1.c1ccc(-c2ccccn2)nc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1 |
TUCAN
C62H61N4OP2RuS/(1-110)(2-65)(3-111)(4-66)(5-68)(6-64)(7-69)(8-67)(9-70)(10-74)(11-75)(12-76)(13-93)(14-112)(15-112)(16-77)(17-73)(18-78)(19-80)(20-79)(21-82)(22-105)(23-106)(24-106)(25-105)(26-92)(27-91)(28-81)(29-71)(30-85)(31-88)(32-90)(33-72)(34-86)(35-87)(36-113)(37-107)(38-107)(39-84)(40-108)(41-108)(42-83)(43-113)(44-89)(45-94)(46-98)(47-97)(48-99)(49-95)(50-100)(51-96)(52-101)(53-62)(54-104)(55-102)(56-62)(57-62)(58-63)(59-63)(60-103)(61-63)(62-106)(63-108)(64-66)(64-68)(65-66)(65-117)(67-69)(67-70)(68-77)(69-78)(70-79)(71-73)(71-80)(72-82)(72-88)(73-81)(74-75)(74-110)(75-76)(76-114)(77-117)(78-118)(79-118)(80-85)(81-119)(82-86)(83-84)(83-104)(84-109)(85-119)(86-120)(87-88)(87-120)(89-90)(89-121)(90-95)(91-92)(91-93)(92-111)(93-115)(94-98)(94-121)(95-98)(96-100)(96-101)(97-100)(97-122)(99-101)(99-122)(102-103)(102-109)(103-104)(105-106)(105-112)(107-108)(107-113)(109-116)(110-125)(111-126)(112-124)(113-124)(114-115)(114-125)(115-126)(116-127)(116-128)(117-129)(118-129)(119-129)(120-130)(121-130)(122-130)(123-124)(123-127)(123-131)(125-132)(126-132)(127-132)(129-132)(130-132)
Measurements (2)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MCF-10A | 7.9 | — | 10.1016/j.jinorgbio.2018.05.01... | 2018 |
| MDA-MB-231 | 22 | — | 10.1016/j.jinorgbio.2018.05.01... | 2018 |
🧬 Cell Death Types (1)
Apoptosis
high
«Complex (2) inhibited proliferation, migration, invasion, adhesion, changed morphology and induced apoptosis, DNA damage and nuclear fragmentation of TNBC cells ... Complex (2) was able to induce apop...»