Info
| ID | 354 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"O": 1, "N": 2, "P": 1} |
| Abbreviation | Ru4 |
| SMILES | O=C[c-]1cccc1.c1ccc(-c2ccccn2)nc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1 |
TUCAN
C34H28N2OPRu/(1-29)(2-36)(3-37)(4-55)(5-32)(6-31)(7-30)(8-47)(9-39)(10-48)(11-40)(12-35)(13-43)(14-56)(15-46)(16-38)(17-50)(18-51)(19-52)(20-49)(21-42)(22-45)(23-53)(24-33)(25-44)(26-34)(27-59)(28-41)(29-31)(29-60)(30-31)(30-39)(32-35)(32-57)(33-34)(33-44)(34-54)(35-52)(36-39)(36-60)(37-40)(37-61)(38-40)(38-46)(41-44)(41-54)(42-43)(42-53)(43-58)(45-50)(45-51)(46-47)(47-61)(48-50)(48-62)(49-51)(49-62)(52-55)(53-56)(54-59)(55-63)(56-64)(57-58)(57-63)(58-64)(59-65)(60-66)(61-66)(62-66)(63-67)(64-67)(66-67)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MCF-7 | 0.37 | — | 10.1016/j.jinorgbio.2023.11243... | 2024 |
| MDA-MB-231 | 1.4 | — | 10.1016/j.jinorgbio.2023.11243... | 2024 |
| RKO | 4.1 | — | 10.3390/pharmaceutics14061293 | 2022 |
| V79 | 13 | — | 10.1016/j.jinorgbio.2023.11243... | 2024 |
| SW480 | 27 | — | 10.3390/pharmaceutics14061293 | 2022 |
🧬 Cell Death Types (1)
Apoptosis
high
«Based on the results obtained with this assay, we conclude that these compounds induced cell death by apoptosis.»