Info
| ID | 3532 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 3} |
| Abbreviation | 1 |
| SMILES | CC(C)c1cccc(C(C)C)c1/N=C/c1ncc[nH]1.Cc1ccc(C(C)C)cc1.[Cl-] |
TUCAN
C26H35N3Ru/(1-54)(2-36)(3-36)(4-43)(5-57)(6-37)(7-46)(8-37)(9-37)(10-44)(11-40)(12-40)(13-40)(14-38)(15-38)(16-38)(17-48)(18-39)(19-47)(20-55)(21-39)(22-39)(23-41)(24-41)(25-41)(26-36)(27-45)(28-58)(29-59)(30-42)(31-42)(32-49)(33-42)(34-56)(35-62)(36-50)(37-54)(38-55)(39-55)(40-54)(41-56)(42-56)(43-44)(43-51)(44-50)(45-46)(45-50)(46-51)(47-48)(47-52)(48-49)(49-53)(51-54)(52-55)(52-60)(53-56)(53-60)(57-58)(57-62)(58-63)(59-61)(59-64)(60-64)(61-62)(61-63)(63-65)(64-65)
Measurements (7)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HFF-1 | 6 | — | 10.1039/c5dt04781a | 2016 |
| HeLa | 7.4 | — | 10.1039/c4dt03983a | 2015 |
| HepG2 | 8 | — | 10.1039/c5dt04781a | 2016 |
| NIH-3T3 | 9.2 | — | 10.1039/c5dt04781a | 2016 |
| MIA PaCa-2 | 10 | — | 10.1039/c5dt04781a | 2016 |
| MCF-7 | 14 | — | 10.1039/c4dt03983a | 2015 |
| A549 | 23 | — | 10.1039/c4dt03983a | 2015 |
🧬 Cell Death Types (1)
Apoptosis
high
«1 arrests the cell cycle in sub G1 and G2/M phases and leads to apoptosis. The ladder assay of 1 against MCF-7 cells shows that the DNA is cleaved to form nucleosome-sized fragments ... confirming tha...»