Info
| ID | 353 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 2, "P": 1} |
| Abbreviation | Ru3 |
| SMILES | C[c-]1cccc1.OCc1ccnc(-c2cc(CO)ccn2)c1.c1ccc(P(c2ccccc2)c2ccccc2)cc1 |
TUCAN
C36H34N2O2PRu/(1-57)(2-63)(3-55)(4-35)(5-35)(6-36)(7-40)(8-39)(9-37)(10-41)(11-42)(12-43)(13-47)(14-46)(15-49)(16-52)(17-62)(18-66)(19-66)(20-45)(21-50)(22-53)(23-48)(24-67)(25-51)(26-67)(27-44)(28-56)(29-58)(30-38)(31-35)(32-54)(33-74)(34-73)(35-59)(36-40)(36-68)(37-41)(37-68)(38-56)(38-59)(39-40)(39-41)(42-43)(42-47)(43-69)(44-60)(44-64)(45-60)(45-62)(46-49)(46-69)(47-49)(48-50)(48-70)(50-52)(51-53)(51-70)(52-53)(54-58)(54-59)(55-61)(55-63)(56-58)(57-61)(57-65)(60-66)(61-67)(62-72)(63-71)(64-65)(64-72)(65-71)(66-74)(67-73)(68-75)(69-75)(70-75)(71-76)(72-76)(74-76)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A2780 | 2.3 | — | 10.1021/acs.inorgchem.8b00358 | 2018 |
| RKO | 2.8 | — | 10.3390/pharmaceutics14061293 | 2022 |
| A2780cisR | 4.7 | — | 10.1021/acs.inorgchem.8b00358 | 2018 |
| SW480 | 8.2 | — | 10.3390/pharmaceutics14061293 | 2022 |
🧬 Cell Death Types (1)
Apoptosis
high
«Based on the results obtained with this assay, we conclude that these compounds induced cell death by apoptosis.»