Info
| ID | 3526 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 2} |
| Abbreviation | C14 |
| SMILES | O=C(NC(=S)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccco1.[Cl-].[Cl-].c1ccccc1 |
TUCAN
C20Cl2F6N2O2RuS/(1-3)(1-6)(2-9)(2-16)(3-7)(4-12)(4-14)(5-13)(5-14)(6-10)(7-11)(8-12)(8-13)(9-15)(10-11)(12-18)(13-19)(14-21)(15-24)(16-17)(16-24)(17-22)(17-23)(18-25)(18-26)(18-27)(19-28)(19-29)(19-30)(20-21)(20-22)(20-31)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| IMR-32 | 25 | — | 10.1002/chem.202004954 | 2021 |
| HeLa | 27 | — | 10.1002/chem.202004954 | 2021 |
| HepG2 | 39 | — | 10.1002/chem.202004954 | 2021 |
| SW40 | 39 | — | 10.1002/chem.202004954 | 2021 |
| A431 | 46 | — | 10.1002/chem.202004954 | 2021 |
| Vero | 1.2e+02 | — | 10.1002/chem.202004954 | 2021 |
🧬 Cell Death Types (1)
Apoptosis
high
«They also promoted cell death by apoptosis and cell cycle arrest.»