Info
| ID | 3524 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 2} |
| Abbreviation | C12 |
| SMILES | Cc1cc(C)c(NC(=S)NC(=O)c2ccco2)c(C)c1.[Cl-].[Cl-].c1ccccc1 |
TUCAN
C21Cl2N2O2RuS/(1-15)(2-14)(3-16)(4-7)(4-8)(5-10)(5-18)(6-14)(6-15)(7-9)(8-11)(9-12)(10-19)(11-12)(13-14)(13-16)(15-17)(16-17)(17-23)(18-25)(19-20)(19-25)(20-22)(20-24)(21-22)(21-23)(21-26)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| IMR-32 | 17 | — | 10.1002/chem.202004954 | 2021 |
| HeLa | 28 | — | 10.1002/chem.202004954 | 2021 |
| A431 | 33 | — | 10.1002/chem.202004954 | 2021 |
| HepG2 | 35 | — | 10.1002/chem.202004954 | 2021 |
| SW40 | 38 | — | 10.1002/chem.202004954 | 2021 |
| Vero | 1.3e+02 | — | 10.1002/chem.202004954 | 2021 |
🧬 Cell Death Types (1)
Apoptosis
high
«They also promoted cell death by apoptosis and cell cycle arrest.»