Info
| ID | 352 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 2, "P": 1} |
| Abbreviation | Ru2 |
| SMILES | C[c-]1cccc1.Cc1ccnc(-c2cc(C)ccn2)c1.c1ccc(P(c2ccccc2)c2ccccc2)cc1 |
TUCAN
C36H34N2PRu/(1-36)(2-38)(3-42)(4-47)(5-40)(6-41)(7-39)(8-44)(9-54)(10-55)(11-36)(12-46)(13-56)(14-35)(15-35)(16-35)(17-36)(18-43)(19-45)(20-53)(21-57)(22-51)(23-60)(24-58)(25-64)(26-52)(27-49)(28-65)(29-37)(30-50)(31-37)(32-37)(33-48)(34-59)(35-61)(36-62)(37-63)(38-40)(38-68)(39-41)(39-68)(40-46)(41-46)(42-49)(42-61)(43-62)(43-66)(44-45)(44-69)(45-51)(47-62)(47-64)(48-50)(48-61)(49-50)(51-53)(52-57)(52-58)(53-54)(54-69)(55-57)(55-70)(56-58)(56-70)(59-63)(59-65)(60-63)(60-67)(64-71)(65-72)(66-67)(66-71)(67-72)(68-73)(69-73)(70-73)(71-74)(72-74)(73-74)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| RKO | 0.31 | — | 10.3390/pharmaceutics14061293 | 2022 |
| A2780cisR | 0.61 | — | 10.1021/acs.inorgchem.8b00358 | 2018 |
| A2780 | 0.64 | — | 10.1021/acs.inorgchem.8b00358 | 2018 |
| SW480 | 1.4 | — | 10.3390/pharmaceutics14061293 | 2022 |
| NCM460 | 1.5 | — | 10.3390/pharmaceutics14061293 | 2022 |
🧬 Cell Death Types (1)
Apoptosis
high
«Based on the results obtained with this assay, we conclude that these compounds induced cell death by apoptosis.»