home← all complexes D-MPNN

Complex #352 — Ru(2) [Ru2]

2D Structure

Structure
⬇ MOL V3000

Info

ID352
MetalRu
Oxidation state2
Charge1
Donor atoms{"N": 2, "P": 1}
AbbreviationRu2
SMILESC[c-]1cccc1.Cc1ccnc(-c2cc(C)ccn2)c1.c1ccc(P(c2ccccc2)c2ccccc2)cc1

TUCAN

C36H34N2PRu/(1-36)(2-38)(3-42)(4-47)(5-40)(6-41)(7-39)(8-44)(9-54)(10-55)(11-36)(12-46)(13-56)(14-35)(15-35)(16-35)(17-36)(18-43)(19-45)(20-53)(21-57)(22-51)(23-60)(24-58)(25-64)(26-52)(27-49)(28-65)(29-37)(30-50)(31-37)(32-37)(33-48)(34-59)(35-61)(36-62)(37-63)(38-40)(38-68)(39-41)(39-68)(40-46)(41-46)(42-49)(42-61)(43-62)(43-66)(44-45)(44-69)(45-51)(47-62)(47-64)(48-50)(48-61)(49-50)(51-53)(52-57)(52-58)(53-54)(54-69)(55-57)(55-70)(56-58)(56-70)(59-63)(59-65)(60-63)(60-67)(64-71)(65-72)(66-67)(66-71)(67-72)(68-73)(69-73)(70-73)(71-74)(72-74)(73-74)

Measurements (5)

Cell lineIC₅₀ dark (µM)IC₅₀ light (µM)DOIYear
RKO0.31 10.3390/pharmaceutics14061293 2022
A2780cisR0.61 10.1021/acs.inorgchem.8b00358 2018
A27800.64 10.1021/acs.inorgchem.8b00358 2018
SW4801.4 10.3390/pharmaceutics14061293 2022
NCM4601.5 10.3390/pharmaceutics14061293 2022

🧬 Cell Death Types (1)

Apoptosis high
«Based on the results obtained with this assay, we conclude that these compounds induced cell death by apoptosis.»