Info
| ID | 3517 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 2} |
| Abbreviation | C5 |
| SMILES | Cc1cc(C)c(NC(=S)NC(=O)c2ccco2)c(C)c1.Cc1ccc(C(C)C)cc1.[Cl-].[Cl-] |
TUCAN
C25Cl2N2O2RuS/(1-20)(2-18)(3-19)(4-16)(5-17)(6-16)(7-12)(7-22)(8-18)(8-20)(9-11)(9-15)(10-14)(10-15)(11-17)(12-23)(13-19)(13-20)(14-17)(15-16)(18-21)(19-21)(21-27)(22-29)(23-24)(23-29)(24-26)(24-28)(25-26)(25-27)(25-30)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| IMR-32 | 11 | — | 10.1002/chem.202004954 | 2021 |
| HeLa | 17 | — | 10.1002/chem.202004954 | 2021 |
| HepG2 | 17 | — | 10.1002/chem.202004954 | 2021 |
| A431 | 21 | — | 10.1002/chem.202004954 | 2021 |
| SW40 | 26 | — | 10.1002/chem.202004954 | 2021 |
| Vero | 92 | — | 10.1002/chem.202004954 | 2021 |
🧬 Cell Death Types (1)
Apoptosis
high
«They also promoted cell death by apoptosis and cell cycle arrest.»