Info
| ID | 3510 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 8} |
| Abbreviation | Ru1 |
| SMILES | c1ccc(-c2ccccn2)nc1.c1ccc(-c2ccccn2)nc1.c1csc(-c2nc3c4cccnc4c4ncccc4c3nc2-c2cccs2)c1 |
TUCAN
C42H28N8RuS2/(1-51)(2-32)(3-40)(4-42)(5-29)(6-35)(7-31)(8-44)(9-55)(10-54)(11-34)(12-33)(13-36)(14-67)(15-37)(16-47)(17-52)(18-39)(19-41)(20-45)(21-43)(22-38)(23-30)(24-68)(25-46)(26-53)(27-48)(28-56)(29-31)(29-59)(30-36)(30-67)(31-32)(32-51)(33-34)(33-52)(34-35)(35-60)(36-69)(37-39)(37-68)(38-41)(38-55)(39-70)(40-42)(40-54)(41-50)(42-49)(43-47)(43-53)(44-47)(44-61)(45-48)(45-66)(46-48)(46-56)(49-58)(49-62)(50-63)(50-64)(51-73)(52-74)(53-75)(54-71)(55-77)(56-76)(57-65)(57-70)(57-72)(58-63)(58-71)(59-60)(59-73)(60-74)(61-66)(61-75)(62-64)(62-72)(63-77)(64-78)(65-69)(65-78)(66-76)(67-79)(68-80)(69-79)(70-80)(73-81)(74-81)(75-81)(76-81)(77-81)(78-81)(79-81)(80-81)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MCF-7 | 89 | 5.2 | 10.1021/acs.inorgchem.9b02420 | 2019 |
| HeLa | — | 21 | 10.1021/acs.inorgchem.9b02420 | 2019 |
| A549 | — | 8.3 | 10.1021/acs.inorgchem.9b02420 | 2019 |
🧬 Cell Death Types (1)
Apoptosis
high
«We found that Ru1 itself at a concentration of 40 μM was not enough to induce cell death in the dark but that irradiation was necessary to trigger cell apoptosis. When HeLa cells were incubated with R...»