Info
| ID | 3510 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 8} |
| Abbreviation | Ru1 |
| SMILES | c1ccc(-c2ccccn2)nc1.c1ccc(-c2ccccn2)nc1.c1csc(-c2nc3c4cccnc4c4ncccc4c3nc2-c2cccs2)c1 |
TUCAN
C42H28N8RuS2/(1-51)(2-32)(3-40)(4-42)(5-29)(6-35)(7-31)(8-44)(9-55)(10-54)(11-34)(12-33)(13-36)(14-67)(15-37)(16-47)(17-52)(18-39)(19-41)(20-45)(21-43)(22-38)(23-30)(24-68)(25-46)(26-53)(27-48)(28-56)(29-31)(29-59)(30-36)(30-67)(31-32)(32-51)(33-34)(33-52)(34-35)(35-60)(36-69)(37-39)(37-68)(38-41)(38-55)(39-70)(40-42)(40-54)(41-50)(42-49)(43-47)(43-53)(44-47)(44-61)(45-48)(45-66)(46-48)(46-56)(49-58)(49-62)(50-63)(50-64)(51-73)(52-74)(53-75)(54-71)(55-77)(56-76)(57-65)(57-70)(57-72)(58-63)(58-71)(59-60)(59-73)(60-74)(61-66)(61-75)(62-64)(62-72)(63-77)(64-78)(65-69)(65-78)(66-76)(67-79)(68-80)(69-79)(70-80)(73-81)(74-81)(75-81)(76-81)(77-81)(78-81)(79-81)(80-81)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MCF-7 | 89 | 5.2 | 10.1021/acs.inorgchem.9b02420 | 2019 |
| HeLa | — | 21 | 10.1021/acs.inorgchem.9b02420 | 2019 |
| A549 | — | 8.3 | 10.1021/acs.inorgchem.9b02420 | 2019 |
🧬 Cell Death Types (1)
Apoptosis
high
«We found that Ru1 itself at a concentration of 40 μM was not enough to induce cell death in the dark but that irradiation was necessary to trigger cell apoptosis. When HeLa cells were incubated with R...»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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