Info
| ID | 351 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 2, "P": 1} |
| Abbreviation | Ru1 |
| SMILES | C[c-]1cccc1.c1ccc(-c2ccccn2)nc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1 |
TUCAN
C34H30N2PRu/(1-41)(2-34)(3-31)(4-31)(5-32)(6-33)(7-36)(8-37)(9-44)(10-38)(11-35)(12-31)(13-42)(14-40)(15-48)(16-39)(17-46)(18-43)(19-47)(20-58)(21-45)(22-50)(23-59)(24-49)(25-52)(26-53)(27-51)(28-54)(29-55)(30-56)(31-57)(32-34)(32-62)(33-38)(33-62)(34-36)(35-54)(35-57)(36-38)(37-39)(37-63)(39-43)(40-41)(40-42)(41-58)(42-60)(43-46)(44-46)(44-63)(45-47)(45-50)(47-48)(48-64)(49-50)(49-64)(51-55)(51-57)(52-56)(52-61)(53-56)(53-59)(54-55)(58-65)(59-66)(60-61)(60-65)(61-66)(62-67)(63-67)(64-67)(65-68)(66-68)(67-68)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| RKO | 0.54 | — | 10.3390/pharmaceutics14061293 | 2022 |
| SW480 | 2 | — | 10.3390/pharmaceutics14061293 | 2022 |
| A2780 | 4.2 | — | 10.1021/acs.inorgchem.8b00358 | 2018 |
| A2780cisR | 7.5 | — | 10.1021/acs.inorgchem.8b00358 | 2018 |
🧬 Cell Death Types (1)
Apoptosis
high
«Based on the results obtained with this assay, we conclude that these compounds induced cell death by apoptosis.»