Info
| ID | 3496 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 6} |
| Abbreviation | 7 |
| SMILES | CN(C)c1ccc(/N=C/c2ccc3ccccc3n2)cc1.c1ccc(-c2ccccn2)nc1.c1ccc2cc3nc4c5cccnc5c5ncccc5c4nc3cc2c1 |
TUCAN
C50H37N9Ru/(1-38)(2-42)(3-73)(4-71)(5-75)(6-39)(7-41)(8-43)(9-61)(10-63)(11-74)(12-44)(13-45)(14-69)(15-51)(16-69)(17-55)(18-54)(19-72)(20-59)(21-69)(22-70)(23-50)(24-62)(25-52)(26-40)(27-48)(28-47)(29-60)(30-58)(31-49)(32-56)(33-57)(34-70)(35-46)(36-53)(37-70)(38-57)(38-71)(39-64)(39-78)(40-48)(40-49)(41-42)(41-73)(42-43)(43-82)(44-45)(44-87)(45-81)(46-62)(46-79)(47-49)(47-67)(48-64)(50-53)(50-62)(51-52)(51-87)(52-81)(53-68)(54-55)(54-75)(55-60)(56-67)(56-86)(57-65)(58-59)(58-66)(59-72)(60-83)(61-63)(61-68)(63-80)(64-67)(65-77)(65-84)(66-76)(66-85)(68-79)(69-90)(70-90)(71-94)(72-89)(73-93)(74-80)(74-96)(75-95)(76-77)(76-88)(77-92)(78-86)(78-88)(79-91)(80-91)(81-90)(82-83)(82-93)(83-95)(84-85)(84-94)(85-89)(86-92)(87-96)(91-97)(92-97)(93-97)(94-97)(95-97)(96-97)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HepG2 | 39 | 0.04 | 10.1021/acs.inorgchem.0c01860 | 2020 |
| HepG2 | 39 | 0.063 | 10.1021/acs.inorgchem.0c01860 | 2020 |
| A549 | 43 | 0.038 | 10.1021/acs.inorgchem.0c01860 | 2020 |
| A549 | 43 | 0.056 | 10.1021/acs.inorgchem.0c01860 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«The potential of complexes 4 and 7 and [Ru(bpy)3]Cl2 to induce cell death was determined with blue (465 nm)- and red-light (650 nm) irradiation by using an Annexin V-FITC/propidium iodide (PI) assay. ...»