Info
| ID | 3495 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 6} |
| Abbreviation | 6 |
| SMILES | CN(C)c1ccc(/N=C/c2ccccn2)cc1.c1ccc(-c2ccccn2)nc1.c1ccc2cc3nc4c5cccnc5c5ncccc5c4nc3cc2c1 |
TUCAN
C46H35N9Ru/(1-36)(2-66)(3-65)(4-49)(5-67)(6-68)(7-46)(8-50)(9-52)(10-44)(11-69)(12-42)(13-45)(14-63)(15-63)(16-58)(17-41)(18-43)(19-38)(20-55)(21-63)(22-64)(23-51)(24-37)(25-47)(26-48)(27-57)(28-39)(29-40)(30-56)(31-53)(32-54)(33-64)(34-70)(35-64)(36-54)(36-65)(37-40)(37-47)(38-55)(38-67)(39-60)(39-71)(40-48)(41-49)(41-75)(42-45)(42-80)(43-57)(43-76)(44-52)(44-81)(45-74)(46-49)(46-66)(47-60)(48-59)(50-52)(50-70)(51-58)(51-74)(53-57)(53-68)(54-62)(55-61)(56-59)(56-78)(58-80)(59-60)(61-73)(61-79)(62-72)(62-77)(63-84)(64-84)(65-87)(66-86)(67-83)(68-88)(69-81)(69-90)(70-85)(71-78)(71-82)(72-73)(72-87)(73-83)(74-84)(75-76)(75-86)(76-88)(77-79)(77-89)(78-89)(79-82)(80-90)(81-85)(85-91)(86-91)(87-91)(88-91)(89-91)(90-91)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HepG2 | 40 | 0.045 | 10.1021/acs.inorgchem.0c01860 | 2020 |
| HepG2 | 40 | 0.13 | 10.1021/acs.inorgchem.0c01860 | 2020 |
| A549 | 49 | 0.073 | 10.1021/acs.inorgchem.0c01860 | 2020 |
| A549 | 49 | 0.15 | 10.1021/acs.inorgchem.0c01860 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«The potential of complexes 4 and 7 and [Ru(bpy)3]Cl2 to induce cell death was determined with blue (465 nm)- and red-light (650 nm) irradiation by using an Annexin V-FITC/propidium iodide (PI) assay. ...»