Info
| ID | 3494 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 8} |
| Abbreviation | 5 |
| SMILES | C(=N/c1ccccc1)\c1ccccn1.c1ccc(-c2ccccn2)nc1.c1ccc2cc3nc4c5cccnc5c5ncccc5c4nc3cc2c1 |
TUCAN
C44H30N8Ru/(1-63)(2-59)(3-61)(4-35)(5-37)(6-36)(7-33)(8-41)(9-46)(10-42)(11-49)(12-43)(13-54)(14-51)(15-60)(16-34)(17-39)(18-40)(19-32)(20-53)(21-31)(22-48)(23-47)(24-62)(25-38)(26-50)(27-45)(28-64)(29-44)(30-52)(31-57)(31-70)(32-56)(32-65)(33-34)(33-46)(34-67)(35-36)(35-37)(36-72)(37-44)(38-45)(38-53)(39-41)(39-48)(40-41)(40-57)(42-49)(42-61)(43-44)(43-72)(45-73)(46-59)(47-50)(47-58)(48-56)(49-55)(50-63)(51-54)(51-74)(52-54)(52-64)(53-62)(55-69)(55-71)(56-57)(58-66)(58-68)(59-77)(60-74)(60-82)(61-75)(62-78)(63-81)(64-79)(65-70)(65-80)(66-71)(66-80)(67-73)(67-77)(68-69)(68-81)(69-75)(70-76)(71-76)(72-82)(73-78)(74-79)(77-83)(78-83)(79-83)(80-83)(81-83)(82-83)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HepG2 | 46 | 0.065 | 10.1021/acs.inorgchem.0c01860 | 2020 |
| HepG2 | 46 | 0.23 | 10.1021/acs.inorgchem.0c01860 | 2020 |
| A549 | 52 | 0.089 | 10.1021/acs.inorgchem.0c01860 | 2020 |
| A549 | 52 | 0.24 | 10.1021/acs.inorgchem.0c01860 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«The potential of complexes 4 and 7 and [Ru(bpy)3]Cl2 to induce cell death was determined with blue (465 nm)- and red-light (650 nm) irradiation by using an Annexin V-FITC/propidium iodide (PI) assay. ...»