Info
| ID | 3493 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 7} |
| Abbreviation | 4 |
| SMILES | CN(C)c1ccc(/N=C/c2ccc3ccccc3n2)cc1.c1ccc(-c2ccccn2)nc1.c1ccc(-c2ccccn2)nc1 |
TUCAN
C38H33N7Ru/(1-59)(2-35)(3-60)(4-34)(5-38)(6-39)(7-43)(8-41)(9-61)(10-50)(11-57)(12-57)(13-57)(14-58)(15-58)(16-40)(17-37)(18-45)(19-36)(20-51)(21-53)(22-62)(23-58)(24-48)(25-52)(26-49)(27-46)(28-44)(29-42)(30-47)(31-54)(32-55)(33-63)(34-35)(34-64)(35-38)(36-37)(36-67)(37-39)(38-59)(39-60)(40-43)(40-56)(41-42)(41-43)(42-65)(44-45)(44-46)(45-61)(46-68)(47-54)(47-69)(48-52)(48-70)(49-50)(49-66)(50-71)(51-55)(51-71)(52-56)(53-54)(53-62)(55-66)(56-65)(57-72)(58-72)(59-73)(60-74)(61-76)(62-77)(63-70)(63-75)(64-67)(64-73)(65-78)(66-75)(67-74)(68-69)(68-76)(69-77)(70-78)(71-72)(73-79)(74-79)(75-79)(76-79)(77-79)(78-79)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HepG2 | 46 | 12 | 10.1021/acs.inorgchem.0c01860 | 2020 |
| HepG2 | 46 | 17 | 10.1021/acs.inorgchem.0c01860 | 2020 |
| A549 | 50 | 16 | 10.1021/acs.inorgchem.0c01860 | 2020 |
| A549 | 50 | 19 | 10.1021/acs.inorgchem.0c01860 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«The potential of complexes 4 and 7 and [Ru(bpy)3]Cl2 to induce cell death was determined with blue (465 nm)- and red-light (650 nm) irradiation by using an Annexin V-FITC/propidium iodide (PI) assay. ...»