Info
| ID | 3492 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 6} |
| Abbreviation | 3 |
| SMILES | C(=N/c1ccccc1)\c1ccc2ccccc2n1.c1ccc(-c2ccccn2)nc1.c1ccc(-c2ccccn2)nc1 |
TUCAN
C36H28N6Ru/(1-35)(2-43)(3-47)(4-29)(5-31)(6-37)(7-44)(8-53)(9-45)(10-55)(11-30)(12-33)(13-32)(14-54)(15-34)(16-56)(17-40)(18-51)(19-38)(20-49)(21-57)(22-42)(23-48)(24-41)(25-50)(26-36)(27-46)(28-39)(29-30)(29-35)(30-53)(31-32)(31-43)(32-54)(33-34)(33-44)(34-56)(35-60)(36-40)(36-59)(37-47)(37-58)(38-39)(38-52)(39-61)(40-51)(41-42)(41-48)(42-57)(43-62)(44-63)(45-47)(45-49)(46-50)(46-59)(48-64)(49-52)(50-51)(52-58)(53-65)(54-68)(55-61)(55-66)(56-69)(57-70)(58-67)(59-66)(60-62)(60-65)(61-67)(62-68)(63-64)(63-69)(64-70)(65-71)(66-71)(67-71)(68-71)(69-71)(70-71)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 52 | 23 | 10.1021/acs.inorgchem.0c01860 | 2020 |
| A549 | 52 | 30 | 10.1021/acs.inorgchem.0c01860 | 2020 |
| HepG2 | 56 | 34 | 10.1021/acs.inorgchem.0c01860 | 2020 |
| HepG2 | 56 | 34 | 10.1021/acs.inorgchem.0c01860 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«The potential of complexes 4 and 7 and [Ru(bpy)3]Cl2 to induce cell death was determined with blue (465 nm)- and red-light (650 nm) irradiation by using an Annexin V-FITC/propidium iodide (PI) assay. ...»