Info
| ID | 3491 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 7} |
| Abbreviation | 2 |
| SMILES | CN(C)c1ccc(/N=C/c2ccccn2)cc1.c1ccc(-c2ccccn2)nc1.c1ccc(-c2ccccn2)nc1 |
TUCAN
C34H31N7Ru/(1-53)(2-32)(3-54)(4-33)(5-34)(6-43)(7-42)(8-40)(9-37)(10-49)(11-51)(12-51)(13-51)(14-52)(15-50)(16-58)(17-35)(18-41)(19-44)(20-56)(21-57)(22-52)(23-52)(24-38)(25-55)(26-46)(27-48)(28-47)(29-45)(30-39)(31-36)(32-33)(32-34)(33-53)(34-59)(35-43)(35-54)(36-38)(36-39)(37-42)(37-65)(38-55)(39-64)(40-43)(40-60)(41-44)(41-56)(42-63)(44-46)(45-47)(45-57)(46-61)(47-48)(48-62)(49-50)(49-63)(50-65)(51-66)(52-66)(53-67)(54-68)(55-69)(56-70)(57-71)(58-64)(58-72)(59-60)(59-67)(60-68)(61-62)(61-70)(62-71)(63-66)(64-69)(65-72)(67-73)(68-73)(69-73)(70-73)(71-73)(72-73)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HepG2 | 48 | 26 | 10.1021/acs.inorgchem.0c01860 | 2020 |
| HepG2 | 48 | 37 | 10.1021/acs.inorgchem.0c01860 | 2020 |
| A549 | 52 | 30 | 10.1021/acs.inorgchem.0c01860 | 2020 |
| A549 | 52 | 36 | 10.1021/acs.inorgchem.0c01860 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«The potential of complexes 4 and 7 and [Ru(bpy)3]Cl2 to induce cell death was determined with blue (465 nm)- and red-light (650 nm) irradiation by using an Annexin V-FITC/propidium iodide (PI) assay. ...»