Info
| ID | 3490 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 6} |
| Abbreviation | 1 |
| SMILES | C(=N/c1ccccc1)\c1ccccn1.c1ccc(-c2ccccn2)nc1.c1ccc(-c2ccccn2)nc1 |
TUCAN
C32H26N6Ru/(1-28)(2-31)(3-29)(4-27)(5-30)(6-48)(7-32)(8-46)(9-35)(10-33)(11-34)(12-36)(13-47)(14-49)(15-38)(16-39)(17-50)(18-40)(19-51)(20-52)(21-42)(22-41)(23-44)(24-45)(25-43)(26-37)(27-31)(27-47)(28-31)(28-53)(29-33)(29-54)(30-36)(30-57)(32-39)(32-55)(33-41)(34-36)(34-49)(35-42)(35-58)(37-43)(37-50)(38-45)(38-55)(39-44)(40-42)(40-51)(41-52)(43-46)(44-45)(46-56)(47-59)(48-56)(48-61)(49-60)(50-62)(51-63)(52-64)(53-54)(53-59)(54-64)(55-61)(56-62)(57-58)(57-60)(58-63)(59-65)(60-65)(61-65)(62-65)(63-65)(64-65)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HepG2 | 59 | 24 | 10.1021/acs.inorgchem.0c01860 | 2020 |
| HepG2 | 59 | 40 | 10.1021/acs.inorgchem.0c01860 | 2020 |
| A549 | 64 | 25 | 10.1021/acs.inorgchem.0c01860 | 2020 |
| A549 | 64 | 44 | 10.1021/acs.inorgchem.0c01860 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«The potential of complexes 4 and 7 and [Ru(bpy)3]Cl2 to induce cell death was determined with blue (465 nm)- and red-light (650 nm) irradiation by using an Annexin V-FITC/propidium iodide (PI) assay. ...»