Info
| ID | 3401 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"O": 2, "P": 1} |
| Abbreviation | 6 |
| SMILES | COC(=O)c1ccccc1.CP(c1ccccc1)c1ccc2ccc3cccc4ccc1c2c34.[Cl-].[Cl-] |
TUCAN
C31H25O2PRu/(1-26)(2-33)(3-32)(4-34)(5-27)(6-40)(7-41)(8-31)(9-29)(10-36)(11-54)(12-35)(13-54)(14-37)(15-54)(16-30)(17-28)(18-39)(19-38)(20-42)(21-44)(22-52)(23-52)(24-52)(25-43)(26-28)(26-48)(27-37)(27-55)(28-56)(29-33)(29-45)(30-39)(30-55)(31-32)(31-47)(32-48)(33-49)(34-35)(34-49)(35-36)(36-47)(37-38)(38-39)(40-41)(40-43)(41-51)(42-44)(42-51)(43-44)(45-50)(45-56)(46-47)(46-49)(46-50)(48-50)(51-53)(52-58)(53-57)(53-58)(54-59)(55-59)(56-59)(58-60)(59-60)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| SW620 | 2.7 | — | 10.1021/acs.inorgchem.8b02541 | 2018 |
| A375 | 5.2 | — | 10.1021/acs.inorgchem.8b02541 | 2018 |
| MCF-7 | 7.1 | — | 10.1021/acs.inorgchem.8b02541 | 2018 |
| MCF-10A | 8.9 | — | 10.1021/acs.inorgchem.8b02541 | 2018 |
| A549 | 10 | — | 10.1021/acs.inorgchem.8b02541 | 2018 |
🧬 Cell Death Types (1)
Apoptosis
high
«Complexes 1−6 are all capable of inducing apoptosis, but with various degrees of magnitude.»