Info
| ID | 3400 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"P": 1} |
| Abbreviation | 5 |
| SMILES | CP(c1ccccc1)c1ccc2ccc3cccc4ccc1c2c34.Cc1ccc(C(C)C)cc1.[Cl-].[Cl-] |
TUCAN
C33Cl2PRu/(1-22)(2-22)(3-24)(4-16)(4-27)(5-6)(5-20)(6-12)(7-14)(7-23)(8-17)(8-23)(9-14)(9-26)(10-11)(10-26)(11-28)(12-32)(13-19)(13-33)(15-21)(15-27)(16-24)(17-30)(18-20)(18-32)(19-28)(21-24)(22-27)(23-25)(25-26)(25-29)(28-29)(29-30)(30-33)(31-34)(32-34)(33-34)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| SW620 | 3.1 | — | 10.1021/acs.inorgchem.8b02541 | 2018 |
| A375 | 4.2 | — | 10.1021/acs.inorgchem.8b02541 | 2018 |
| MCF-10A | 4.3 | — | 10.1021/acs.inorgchem.8b02541 | 2018 |
| MCF-7 | 5.4 | — | 10.1021/acs.inorgchem.8b02541 | 2018 |
| A549 | 8.7 | — | 10.1021/acs.inorgchem.8b02541 | 2018 |
🧬 Cell Death Types (1)
Apoptosis
high
«Complexes 1−6 are all capable of inducing apoptosis, but with various degrees of magnitude.»