Info
| ID | 3399 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"O": 2, "P": 1} |
| Abbreviation | 4 |
| SMILES | COC(=O)c1ccccc1.[Cl-].[Cl-].c1ccc(P(c2ccccc2)c2ccc3ccc4cccc5ccc2c3c45)cc1 |
TUCAN
C36H27O2PRu/(1-35)(2-33)(3-34)(4-42)(5-28)(6-44)(7-47)(8-36)(9-41)(10-29)(11-40)(12-31)(13-39)(14-43)(15-32)(16-38)(17-50)(18-37)(19-30)(20-45)(21-48)(22-46)(23-49)(24-59)(25-59)(26-59)(27-51)(28-30)(28-57)(29-31)(29-33)(30-61)(31-32)(32-36)(33-62)(34-40)(34-58)(35-37)(35-58)(36-62)(37-57)(38-43)(38-50)(39-42)(39-56)(40-41)(41-56)(42-55)(43-63)(44-47)(44-54)(45-48)(45-63)(46-47)(46-51)(48-50)(49-51)(49-54)(52-53)(52-56)(52-58)(53-55)(53-57)(54-60)(55-61)(59-65)(60-64)(60-65)(61-66)(62-66)(63-66)(65-67)(66-67)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| SW620 | 8.2 | — | 10.1021/acs.inorgchem.8b02541 | 2018 |
| A375 | 15 | — | 10.1021/acs.inorgchem.8b02541 | 2018 |
| MCF-10A | 17 | — | 10.1021/acs.inorgchem.8b02541 | 2018 |
| MCF-7 | 19 | — | 10.1021/acs.inorgchem.8b02541 | 2018 |
| A549 | 23 | — | 10.1021/acs.inorgchem.8b02541 | 2018 |
🧬 Cell Death Types (1)
Apoptosis
high
«Complexes 1−6 are all capable of inducing apoptosis, but with various degrees of magnitude.»