Info
| ID | 3398 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"P": 1} |
| Abbreviation | 3 |
| SMILES | Cc1ccc(C(C)C)cc1.[Cl-].[Cl-].c1ccc(P(c2ccccc2)c2ccc3ccc4cccc5ccc2c3c45)cc1 |
TUCAN
C38Cl2PRu/(1-28)(2-31)(3-31)(4-6)(4-17)(5-18)(5-27)(6-37)(7-21)(7-27)(8-10)(8-17)(9-11)(9-28)(10-37)(11-33)(12-16)(12-33)(13-14)(13-32)(14-35)(15-19)(15-22)(16-28)(18-36)(19-38)(20-25)(20-34)(21-34)(22-23)(23-26)(24-25)(24-35)(26-38)(27-30)(29-30)(29-34)(29-35)(30-32)(31-33)(32-36)(36-39)(37-39)(38-39)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A375 | 25 | — | 10.1021/acs.inorgchem.8b02541 | 2018 |
| SW620 | 29 | — | 10.1021/acs.inorgchem.8b02541 | 2018 |
| MCF-10A | 35 | — | 10.1021/acs.inorgchem.8b02541 | 2018 |
| MCF-7 | 36 | — | 10.1021/acs.inorgchem.8b02541 | 2018 |
| A549 | 75 | — | 10.1021/acs.inorgchem.8b02541 | 2018 |
🧬 Cell Death Types (1)
Apoptosis
high
«Complexes 1−6 are all capable of inducing apoptosis, but with various degrees of magnitude.»